• Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex 

      Pottel, Hans; Björk, Jonas; Rule, Andrew D.; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Vidal-Petiot, Emmanuelle; Grubb, Anders; Hansson, Magnus; Lamb, Edmund J.; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Flamant, Martin; Nyman, Ulf; Delanaye, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-26)
      BACKGROUND - The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is ...
    • Data on the relation between renal biomarkers and measured glomerular filtration rate 

      Pottel, Hans; Dubourg, Laurence; Schaeffner, Elke; Eriksen, Bjørn Odvar; Melsom, Toralf; Lamb, Edmund J.; Rule, Andrew D.; Turner, Stephen T; Glassock, Richard J.; De Souza, Vandrea; Selistre, Luciano; Goffin, Karolien; Pauwels, Steven; Mariat, Christophe; Flamant, Martin; Bevc, Sebastjan; Delanaye, Pierre; Ebert, Natalie (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10)
      The data presented in this article are related to the research article entitled “The Diagnostic Value of Rescaled Renal Biomarkers Serum Creatinine and Serum Cystatin C and their Relation with Measured Glomerular Filtration Rate” (Pottel et al. (2017) [1]). Data are presented demonstrating the rationale for the normalization or rescaling of serum cystatin C, equivalent to the rescaling of serum ...
    • Iohexol Plasma Clearance: Impact of Weighing the Syringe 

      Delanaye, Pierre; Melsom, Toralf; Cavalier, Etienne; Pottel, Hans; Eriksen, Bjørn Odvar; Dubourg, Laurence (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-05)
      Measured glomerular filtration rate (mGFR) measurement is necessary in specific patients and/or specific clinical contexts.1–3 Plasma clearances are the preferred methods, as they are less costly and cumbersome than urinary clearances.4 The contrast medium iohexol is the most commonly used worldwide, partly for pragmatic reasons, as this marker is stable, not radioactive, and its measurement ...
    • Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa 

      Delanaye, Pierre; Vidal-Petiot, Emmanuelle; Björk, Jonas; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Grubb, Anders; Hansson, Magnus; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla B.; Åsling-Monemi, Kajsa; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Dalton, R Neil; Courbebaisse, Marie; Couzi, Lionel; Gaillard, Francois; Garrouste, Cyril; Jacquemont, Lola; Kamar, Nassim; Legendre, Christophe; Rostaing, Lionel; Stehlé, Thomas; Haymann, Jean-Philippe; Selistre, Luciano da Silva; Strogoff-de-Matos, Jorge P.; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Nyman, Ulf; Pottel, Hans; Flamant, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Background - A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.<p> <p>Methods - Standardized creatinine and measured glomerular ...
    • Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment 

      Delanaye, Pierre; Björk, Jonas; Courbebaisse, Marie; Couzi, Lionel; Ebert, Natalie; Eriksen, Bjørn Odvar; Dalton, R. Neil; Dubourg, Laurence; Melsom, Toralf; Nyman, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
      <p><i>Aim:</i> The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. <p><i>Methods:</i> In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), ...
    • Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study 

      Bjõrk, Jonas; Nyman, Ulf; Courbebaisse, Marie; Couzi, Lionel; Dalton, R. Neil; Dubourg, Laurence; Ebert, Natalie; Eriksen, Bjõrn O.; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Hansson, Magnus; Jacquemont1, Lola; Jones, Ian; Kamar, Nassim; Lamb, Edmund J.; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Turner, Stephen; Åkesson, Anna; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-13)
      Background - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods ...